Bcr 2000 yahoo
We have reported here that miR-223 downregulation affects the transcription factor MEF2C and alternative splicing factor PTBP2. The lab is always open to any new ideas by a student or a post-doc or a researcher, as long as it falls within the themes that drive research activities of the lab.īCR-ABL mediated repression of miR-223 results in the activation of MEF2C and PTBP2 in chronic myeloid leukemia dynamics of post-translational modification(s) of EVI1 in metastasis in colorectal cancer, and several others.identification of targets of EVI1 and decoding their role(s) in leukemogenesis/oncogenesis,.consequences of alternative splicing in the progression of CML,.mechanism(s) of drug resistance in CML stem cells,.homing of leukemic stem cells with respect to normal hematopoietic stem cells,.Whether the cellular mechanisms coordinating post-translational modification(s) of EVI1, support leukemogenesis/oncogenesis, remains to be determined. Multiple post-translational modifications on a protein constitute a complex regulatory program that transduces molecular information to and from signalling pathways. Post-translational protein modification plays an important role in multiple cellular processes including DNA repair, protein stability, nuclear translocation, protein-protein interactions, and in cellular proliferation, differentiation and apoptosis.
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Consequences of post-translational modification of the proto-oncogene EVI1 in leukemia and stem cells The research findings may lead to the development of targeted molecular therapies that can eliminate the disease before it leads to progression.Ģ.
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In this regard, we are looking into the molecular mechanisms that delineate CML stem cells from normal haematopoietic stem cells. Chronic myeloid leukemia (CML) disease progressionĬomplete understanding of the role of specific regulators (known or novel) in the progression of a disease can have a profound impact on the diagnosis, therapy, and ultimately survival of the patients. Two broad themes drive research activities of the lab,ġ. supervisor of Utkal University and RCB, Faridabad. of India.īio-safety Committee, National Institute of Science, Education and Research, (NISER) Bhubaneswar, India.Īmerican Association of Cancer Research (AACR) Indian Association of Cancer Research (IACR)Ĭhronic disease biology (CDB) Task force, Dept. Project: Development of Myelodysplastic Syndrome (MDS) in mice.
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Stem Cell Institute, Katholieke Universiteit, Leuven, Belgium. ICMR International Fellowship, Feb to July, 2011 Ph.D in Science (Microbiology): National Institute of Cholera and Enteric Diseases, Calcutta. Research Associate: You can write to me at details: Please check for openings (if any) that are available in my lab under the positions tab